Nonparametric Identification of the Minimum Effective Dose
نویسندگان
چکیده
منابع مشابه
Nonparametric identification of the minimum effective dose.
We consider identifying the minimum effective dose (MED) in a dose-response study, where the MED is defined to be the lowest dose level producing an effect over that of the zero-dose control. Proposed herein is a nonparametric procedure based on the Mann-Whitney statistic incorporated with the step-down closed testing scheme. A numerical example demonstrates the feasibility of the proposed nonp...
متن کاملNonparametric procedures for simultaneous identification of the minimum effective dose in each of several groups.
This paper considers the extension of the dose finding problem in a one-way layout setting to the case of several groups, in which the main goal is to identify the minimum effective dose (MED) of each group simultaneously. We propose two nonparametric procedures using the respective pairwise- and Helmert-type two-sample Mann-Whitney statistics, which are applied in a step-down testing scheme fo...
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One primary purpose in a dose–response study for drug development is to identify the minimum effective dose (MED), which is the lowest dose level producing an effect over that of the zero-dose control. Proposed herein is a nonparametric step-down closed testing procedure for identifying the MED in a randomized block design with one or more observations per cell. The associated p-value of the id...
متن کاملIdentification of the minimum effective dose for right-censored survival data
In this paper, we consider identifying the minimum effective dose (MED) in a dose–response study when survival data are subject to random right-censorship, where the MED is defined to be the smallest dose level under study that has survival advantage over the zero-dose control. To this end, we suggest single-step-down testing procedures based on three different types of weighted logrank statist...
متن کاملStepwise confidence interval method for Identification of the Minimum Effective Dose
Now we extend one method into a sequence of binomial data, propose a stepwise confidence interval method for toxicity study and can identify a minimum effective dose. The first one is based on the well-known conditional confidence intervals for odds ratio, and the other one comes from Santner (1993)." small-sample confidence intervals for the difference of two success probabilities", and it pro...
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ژورنال
عنوان ژورنال: Biometrics
سال: 1999
ISSN: 0006-341X
DOI: 10.1111/j.0006-341x.1999.01236.x